![]() The test was developed upon the observation that certain serotypes of Proteus bacteria display antigenic cross-reactivity with Rickettsia species. They are closely related and are traditionally separated into 3 groups: the epidemic and endemic typhus group, scrub typhus group, and the spotted fever group. ![]() The known pathogenic rickettsia species are gram-negative, obligate intracellular bacteria that include an increasing number of identified organisms belonging to seven genera ( Rickettsia, Orientia, Ehrlichia, Anaplasma, Neorickettsia, Candidatus, Neoehrlichia, and Coxiella). While it has largely been replaced with new serological techniques, the Weil-Felix test continues to hold great importance in resource-limited areas where more advanced methods are unavailable. ![]() ![]() First described in 1916, the Weil-Felix reaction is a test used in the diagnosis of rickettsial infections.
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